NRF2_phosphorylated_Nucleus -> Nrf2_Maf_complex
MAF -> Nrf2_Maf_complex
MAF -> BACH1_Maf_complex
BACH1 -> BACH1_Maf_complex
CAND1 -| csa8_Ubiquitin_Ligase_Complex_complex_Cytosol
CUL3_RBX1_complex -> csa8_Ubiquitin_Ligase_Complex_complex_Cytosol
NRF2_empty -> csa8_Ubiquitin_Ligase_Complex_complex_Cytosol
KEAP1 -> csa8_Ubiquitin_Ligase_Complex_complex_Cytosol
Dimethly_fumarate_drug -| csa8_Ubiquitin_Ligase_Complex_complex_Cytosol
csa8_Ubiquitin_Ligase_Complex_complex_Cytosol -> csa10_Ubiquitin_Ligase_Complex_complex_Cytosol
NLRP3_elicitors_NLRP3_oligomer_ASC_complex -> NLRP3_elicitors_NLRP3_oligomer_ASC_Procaspase1_complex
proCaspase_1 -> NLRP3_elicitors_NLRP3_oligomer_ASC_Procaspase1_complex
SLC40A1_rna -> SLC40A1_CP_Cu2__complex
NLRP3_elicitors_NLRP3_oligomer_complex -> NLRP3_elicitors_NLRP3_oligomer_ASC_complex
ASC -> NLRP3_elicitors_NLRP3_oligomer_ASC_complex
NLRP3_elicitors_NLRP3_oligomer_ASC_Procaspase1_complex -> NLRP3_elicitors_NLRP3_oligomer_ASC_complex
CTSG -> NLRP3_elicitors_NLRP3_oligomer_ASC_complex
TFRC_TF_complex_Cytosol -> TFRC_holoTF_complex_Cytosol
Fe3__ion_default_compartment -> TFRC_holoTF_complex_Cytosol
Transferrin -> TFRC_holoTF_complex_Cytosol
TFRC_holoTF_complex_Cytosol -> TFRC_holoTF_complex_Endosome_Lumen
TFRC_holoTF_complex_Endosome_Lumen -> TFRC_TF_complex_Endosome_Lumen
TFRC_TF_complex_Endosome_Lumen -> TFRC_TF_complex_Cytosol
csa10_Ubiquitin_Ligase_Complex_complex_Cytosol -> csa32_Ubiquitin_Ligase_Complex_complex_Cytosol
NLRP3_elicitors_NLRP3_complex -> NLRP3_elicitors_NLRP3_oligomer_complex
NLRP3_Elicitor_Proteins -> NLRP3_SUGT1_HSP90_complex
NLRP3_SUGT1_HSP90_complex -> NLRP3_SUGT1_HSP90_complex
NLRP3_Elicitor_Small_Molecules_simple_molecule -> NLRP3_SUGT1_HSP90_complex
NLRP3 -> NLRP3_SUGT1_HSP90_complex
TXNIP_NLRP3_complex -> NLRP3_SUGT1_HSP90_complex
SARS_E -> NLRP3_SUGT1_HSP90_complex
SARS_Orf3a -> NLRP3_SUGT1_HSP90_complex
sa524_Reactive_Oxygen_Species_simple_molecule_Cytosol -> NLRP3_SUGT1_HSP90_complex
TXNIP -> Thioredoxin_TXNIP_complex
TXN -> Thioredoxin_TXNIP_complex
BLVRA_rna -> BLVRA_Zn2__complex
NLRP3_Elicitor_Small_Molecules_simple_molecule -> NLRP3_elicitors_NLRP3_complex
NLRP3_SUGT1_HSP90_complex -> NLRP3_elicitors_NLRP3_complex
NLRP3_Elicitor_Proteins -> NLRP3_elicitors_NLRP3_complex
NLRP3 -> TXNIP_NLRP3_complex
TXNIP -> TXNIP_NLRP3_complex
Pyrin_trimer_complex -> PSTPIP1_trimer_Pyrin_trimer_complex
PSTPIP1 -> PSTPIP1_trimer_Pyrin_trimer_complex
dsDNA_AIM2_complex -> dsDNA_AIM2_oligomer_complex
dsDNA_AIM2_oligomer_complex -> dsDNA_AIM2_oligomer_ASC_complex
ASC -> dsDNA_AIM2_oligomer_ASC_complex
Double_Strand_DNA_simple_molecule -> dsDNA_AIM2_complex
AIM2 -> dsDNA_AIM2_complex
ASC -> Pyrin_trimer_ASC_complex
Pyrin_trimer_complex -> Pyrin_trimer_ASC_complex
dsDNA_AIM2_oligomer_ASC_complex -> dsDNA_AIM2_oligomer_ASC_Procaspase_1_complex
proCaspase_1 -> dsDNA_AIM2_oligomer_ASC_Procaspase_1_complex
FTH1_rna -> Ferritin_complex
FTL_rna -> Ferritin_complex
Bilirubin_simple_molecule -> ALB_BIL_complex
ABCC1 -> ALB_BIL_complex
CASP1_120_197__CASP1_317_404__complex -> Caspase_1_Tetramer_complex
NLRP3_elicitors_NLRP3_oligomer_ASC_Procaspase1_complex -> CASP1_120_197__CASP1_317_404__complex
CTSG -> CASP1_120_197__CASP1_317_404__complex
Heme_simple_molecule_Mitochondrial_Matrix -> Heme_simple_molecule_Cytosol
FLVCR1_2 -> Heme_simple_molecule_Cytosol
Heme_simple_molecule_Cytosol -> Biliverdin_simple_molecule
sa24_O2_simple_molecule_Cytosol -> Biliverdin_simple_molecule
sa25_NADPH_simple_molecule_Cytosol -> Biliverdin_simple_molecule
sa168_HMOX1_Cytosol -> Biliverdin_simple_molecule
PRIN9_simple_molecule_Mitochondrial_Matrix -> Heme_simple_molecule_Mitochondrial_Matrix
Fe2__ion_Mitochondrial_Matrix -> Heme_simple_molecule_Mitochondrial_Matrix
FECH -> Heme_simple_molecule_Mitochondrial_Matrix
Pb2__ion -| Heme_simple_molecule_Mitochondrial_Matrix
Heme_simple_molecule_Cytosol -> sa26_H2O_simple_molecule_Cytosol
sa24_O2_simple_molecule_Cytosol -> sa26_H2O_simple_molecule_Cytosol
sa25_NADPH_simple_molecule_Cytosol -> sa26_H2O_simple_molecule_Cytosol
sa168_HMOX1_Cytosol -> sa26_H2O_simple_molecule_Cytosol
Heme_simple_molecule_Cytosol -> sa27_NADP__simple_molecule_Cytosol
sa24_O2_simple_molecule_Cytosol -> sa27_NADP__simple_molecule_Cytosol
sa25_NADPH_simple_molecule_Cytosol -> sa27_NADP__simple_molecule_Cytosol
sa168_HMOX1_Cytosol -> sa27_NADP__simple_molecule_Cytosol
Heme_simple_molecule_Cytosol -> sa28_Fe2__ion_Cytosol
sa24_O2_simple_molecule_Cytosol -> sa28_Fe2__ion_Cytosol
sa25_NADPH_simple_molecule_Cytosol -> sa28_Fe2__ion_Cytosol
sa168_HMOX1_Cytosol -> sa28_Fe2__ion_Cytosol
sa162_Fe2__ion_default_compartment -> sa28_Fe2__ion_Cytosol
SLC11A2 -> sa28_Fe2__ion_Cytosol
sa240_Fe2__ion_Cytosol -> sa28_Fe2__ion_Cytosol
HMOX1_rna -> sa29_HMOX1_Cytosol
Heme_simple_molecule_Cytosol -> CO_simple_molecule
sa24_O2_simple_molecule_Cytosol -> CO_simple_molecule
sa25_NADPH_simple_molecule_Cytosol -> CO_simple_molecule
sa168_HMOX1_Cytosol -> CO_simple_molecule
Biliverdin_simple_molecule -> Bilirubin_simple_molecule
sa33_NADPH_simple_molecule_Cytosol -> Bilirubin_simple_molecule
BLVRB -> Bilirubin_simple_molecule
BLVRA_Zn2__complex -> Bilirubin_simple_molecule
Biliverdin_simple_molecule -> sa34_NADP__simple_molecule_Cytosol
sa33_NADPH_simple_molecule_Cytosol -> sa34_NADP__simple_molecule_Cytosol
BLVRB -> sa34_NADP__simple_molecule_Cytosol
BLVRA_Zn2__complex -> sa34_NADP__simple_molecule_Cytosol
BLVRB_rna -> BLVRB
Orf9c -> ABCC1
NRF2_phosphorylated_Cytosol -> NRF2_phosphorylated_Nucleus
miRNA_155_rna -| BACH1
Nrf2_Maf_complex -> HMOX1_rna
BACH1_Maf_complex -| HMOX1_rna
FECH_rna -> FECH
PRIN9_simple_molecule_Mitochondrion -> PRIN9_simple_molecule_Mitochondrial_Matrix
PRIN9_simple_molecule_Mitochondrial_Matrix -> sa57_H__ion_Mitochondrial_Matrix
Fe2__ion_Mitochondrial_Matrix -> sa57_H__ion_Mitochondrial_Matrix
FECH -> sa57_H__ion_Mitochondrial_Matrix
Pb2__ion -| sa57_H__ion_Mitochondrial_Matrix
SUCC_CoA_simple_molecule -> dALA_simple_molecule_Mitochondrial_Matrix
Gly_simple_molecule -> dALA_simple_molecule_Mitochondrial_Matrix
sa67_H__ion_Mitochondrial_Matrix -> dALA_simple_molecule_Mitochondrial_Matrix
ALAS1_ALAS2_complex -> dALA_simple_molecule_Mitochondrial_Matrix
Heme_simple_molecule_Mitochondrial_Matrix -| dALA_simple_molecule_Mitochondrial_Matrix
Panhematin_drug -| dALA_simple_molecule_Mitochondrial_Matrix
SUCC_CoA_simple_molecule -> CO2_simple_molecule_Mitochondrial_Matrix
Gly_simple_molecule -> CO2_simple_molecule_Mitochondrial_Matrix
sa67_H__ion_Mitochondrial_Matrix -> CO2_simple_molecule_Mitochondrial_Matrix
ALAS1_ALAS2_complex -> CO2_simple_molecule_Mitochondrial_Matrix
Heme_simple_molecule_Mitochondrial_Matrix -| CO2_simple_molecule_Mitochondrial_Matrix
Panhematin_drug -| CO2_simple_molecule_Mitochondrial_Matrix
SUCC_CoA_simple_molecule -> CoA_SH_simple_molecule
Gly_simple_molecule -> CoA_SH_simple_molecule
sa67_H__ion_Mitochondrial_Matrix -> CoA_SH_simple_molecule
ALAS1_ALAS2_complex -> CoA_SH_simple_molecule
Heme_simple_molecule_Mitochondrial_Matrix -| CoA_SH_simple_molecule
Panhematin_drug -| CoA_SH_simple_molecule
dALA_simple_molecule_Mitochondrial_Matrix -> dALA_simple_molecule_Cytosol
dALA_simple_molecule_Cytosol -> PBG_simple_molecule
ALAD_Zn2__complex -> PBG_simple_molecule
dALA_simple_molecule_Cytosol -> sa103_H2O_simple_molecule_Cytosol
ALAD_Zn2__complex -> sa103_H2O_simple_molecule_Cytosol
dALA_simple_molecule_Cytosol -> sa104_H__ion_Cytosol
ALAD_Zn2__complex -> sa104_H__ion_Cytosol
PBG_simple_molecule -> HMBL_simple_molecule
sa106_H2O_simple_molecule_Cytosol -> HMBL_simple_molecule
HMBS_DIPY_complex -> HMBL_simple_molecule
PBG_simple_molecule -> NH4__ion
sa106_H2O_simple_molecule_Cytosol -> NH4__ion
HMBS_DIPY_complex -> NH4__ion
HMBL_simple_molecule -> URO3_simple_molecule
UROS -> URO3_simple_molecule
URO3_simple_molecule -> COPRO3_simple_molecule_Cytosol
UROD -> COPRO3_simple_molecule_Cytosol
COPRO3_simple_molecule_Cytosol -> COPRO3_simple_molecule_Mitochondrion
COPRO3_simple_molecule_Mitochondrion -> PPGEN9_simple_molecule
sa121_O2_simple_molecule_Mitochondrion -> PPGEN9_simple_molecule
CPOX -> PPGEN9_simple_molecule
PPGEN9_simple_molecule -> PRIN9_simple_molecule_Mitochondrion
sa124_O2_simple_molecule_Mitochondrion -> PRIN9_simple_molecule_Mitochondrion
PPO_FAD_complex -> PRIN9_simple_molecule_Mitochondrion
COPRO3_simple_molecule_Mitochondrion -> CO2_simple_molecule_Mitochondrion
sa121_O2_simple_molecule_Mitochondrion -> CO2_simple_molecule_Mitochondrion
CPOX -> CO2_simple_molecule_Mitochondrion
COPRO3_simple_molecule_Mitochondrion -> sa123_H2O2_simple_molecule_Mitochondrion
sa121_O2_simple_molecule_Mitochondrion -> sa123_H2O2_simple_molecule_Mitochondrion
CPOX -> sa123_H2O2_simple_molecule_Mitochondrion
PPGEN9_simple_molecule -> sa125_H2O2_simple_molecule_Mitochondrion
sa124_O2_simple_molecule_Mitochondrion -> sa125_H2O2_simple_molecule_Mitochondrion
PPO_FAD_complex -> sa125_H2O2_simple_molecule_Mitochondrion
Lipid_Peroxide_simple_molecule -> Ferroptosis_phenotype
Poly_unsaturated_fatty_acid_simple_molecule -> Lipid_Peroxide_simple_molecule
sa165_Reactive_Oxygen_Species_simple_molecule_Cytosol -> Lipid_Peroxide_simple_molecule
sa28_Fe2__ion_Cytosol -> sa135_Fe2__ion_default_compartment
SLC40A1_CP_Cu2__complex -> sa135_Fe2__ion_default_compartment
SLC40A1_HEPH_Cu2__complex -> sa135_Fe2__ion_default_compartment
sa135_Fe2__ion_default_compartment -> Fe3__ion_default_compartment
sa156_O2_simple_molecule_default_compartment -> Fe3__ion_default_compartment
sa157_H__ion_default_compartment -> Fe3__ion_default_compartment
SLC40A1_CP_Cu2__complex -> Fe3__ion_default_compartment
sa212_H__ion_default_compartment -> Fe3__ion_default_compartment
sa213_O2_simple_molecule_default_compartment -> Fe3__ion_default_compartment
SLC40A1_HEPH_Cu2__complex -> Fe3__ion_default_compartment
NRF2_phosphorylated_Nucleus -> SLC40A1_rna
NRF2_phosphorylated_Nucleus -> FTH1_rna
NRF2_phosphorylated_Nucleus -> FTL_rna
NRF2_phosphorylated_Nucleus -> FECH_rna
NRF2_phosphorylated_Nucleus -> BLVRA_rna
NRF2_phosphorylated_Nucleus -> BLVRB_rna
sa28_Fe2__ion_Cytosol -> Fe_3__O_OH__simple_molecule
sa136_O2_simple_molecule_Cytosol -> Fe_3__O_OH__simple_molecule
sa137_H__ion_Cytosol -> Fe_3__O_OH__simple_molecule
Ferritin_complex -> Fe_3__O_OH__simple_molecule
sa135_Fe2__ion_default_compartment -> sa158_H2O_simple_molecule_default_compartment
sa156_O2_simple_molecule_default_compartment -> sa158_H2O_simple_molecule_default_compartment
sa157_H__ion_default_compartment -> sa158_H2O_simple_molecule_default_compartment
SLC40A1_CP_Cu2__complex -> sa158_H2O_simple_molecule_default_compartment
Fe3__ion_default_compartment -> sa162_Fe2__ion_default_compartment
e__ion_default_compartment -> sa162_Fe2__ion_default_compartment
CYBRD1_Heme_complex -> sa162_Fe2__ion_default_compartment
sa28_Fe2__ion_Cytosol -> sa165_Reactive_Oxygen_Species_simple_molecule_Cytosol
Lipid_Peroxide_simple_molecule -> Lipid_alcohol_simple_molecule
GPX4 -> Lipid_alcohol_simple_molecule
sa29_HMOX1_Cytosol -> sa168_HMOX1_Cytosol
SARS_CoV_2_Orf3a -> sa168_HMOX1_Cytosol
NRF2_empty -> NRF2_phosphorylated_Cytosol
PKC -> NRF2_phosphorylated_Cytosol
Heme_simple_molecule_Cytosol -> Heme_simple_molecule_default_compartment
FLVCR1_1 -> Heme_simple_molecule_default_compartment
sa206_H2O_simple_molecule_Cytosol -> Heme_simple_molecule_default_compartment
ATP_simple_molecule -> Heme_simple_molecule_default_compartment
ABCG2 -> Heme_simple_molecule_default_compartment
Heme_simple_molecule_Cytosol -> ADP_simple_molecule
sa206_H2O_simple_molecule_Cytosol -> ADP_simple_molecule
ATP_simple_molecule -> ADP_simple_molecule
ABCG2 -> ADP_simple_molecule
Heme_simple_molecule_Cytosol -> Pi_simple_molecule
sa206_H2O_simple_molecule_Cytosol -> Pi_simple_molecule
ATP_simple_molecule -> Pi_simple_molecule
ABCG2 -> Pi_simple_molecule
sa135_Fe2__ion_default_compartment -> sa211_H2O_simple_molecule_default_compartment
sa212_H__ion_default_compartment -> sa211_H2O_simple_molecule_default_compartment
sa213_O2_simple_molecule_default_compartment -> sa211_H2O_simple_molecule_default_compartment
SLC40A1_HEPH_Cu2__complex -> sa211_H2O_simple_molecule_default_compartment
TFRC_TF_complex_Cytosol -> Transferrin
TFRC_holoTF_complex_Endosome_Lumen -> Fe3__ion_Endosome_Lumen
Fe3__ion_Endosome_Lumen -> Fe2__ion_Endosome_Lumen
e__ion_Endosome_Lumen -> Fe2__ion_Endosome_Lumen
STEAP3 -> Fe2__ion_Endosome_Lumen
Fe2__ion_Endosome_Lumen -> sa240_Fe2__ion_Cytosol
MCOLN1 -> sa240_Fe2__ion_Cytosol
csa10_Ubiquitin_Ligase_Complex_complex_Cytosol -> NRF2_ubiquitinated
NLRP3_rna -> NLRP3
Oxidized_thioredoxin_TXNIP_complex -> TXNIP
Oxidized_thioredoxin_TXNIP_complex -> 2xHC_TXN
TXN -> 2xHC_TXN
sa493_Reactive_Oxygen_Species_simple_molecule_Cytosol -> 2xHC_TXN
Nf_KB_Complex_complex -> NLRP3_rna
NLRP3_elicitors_NLRP3_oligomer_ASC_Procaspase1_complex -> CASP1_1_119_
CTSG -> CASP1_1_119_
NLRP3_elicitors_NLRP3_oligomer_ASC_Procaspase1_complex -> CASP1_298_316_
CTSG -> CASP1_298_316_
proIL_1B -> proIL_1B_1_116_
Caspase_1_Tetramer_complex -> proIL_1B_1_116_
proIL_18 -> proIL_18_1_36_
Caspase_1_Tetramer_complex -> proIL_18_1_36_
proIL_1B -> IL_1B_Cytosol
Caspase_1_Tetramer_complex -> IL_1B_Cytosol
proIL_18 -> IL_18_Cytosol
Caspase_1_Tetramer_complex -> IL_18_Cytosol
IL_1B_Cytosol -> IL_1B_default_compartment
IL_18_Cytosol -> IL_18_default_compartment
CO_simple_molecule -| sa524_Reactive_Oxygen_Species_simple_molecule_Cytosol
$2xHC_TXN: (Oxidized_thioredoxin_TXNIP_complex | (TXN & sa493_Reactive_Oxygen_Species_simple_molecule_Cytosol))
$ABCC1: Orf9c
$ADP_simple_molecule: (((Heme_simple_molecule_Cytosol & sa206_H2O_simple_molecule_Cytosol) & ATP_simple_molecule) & ABCG2)
$ALB_BIL_complex: (Bilirubin_simple_molecule & ABCC1)
$BACH1: !miRNA_155_rna
$BACH1_Maf_complex: (MAF & BACH1)
$BLVRA_Zn2__complex: BLVRA_rna
$BLVRA_rna: NRF2_phosphorylated_Nucleus
$BLVRB: BLVRB_rna
$BLVRB_rna: NRF2_phosphorylated_Nucleus
$Bilirubin_simple_molecule: (((BLVRB | BLVRA_Zn2__complex) & Biliverdin_simple_molecule) & sa33_NADPH_simple_molecule_Cytosol)
$Biliverdin_simple_molecule: (((Heme_simple_molecule_Cytosol & sa24_O2_simple_molecule_Cytosol) & sa25_NADPH_simple_molecule_Cytosol) & sa168_HMOX1_Cytosol)
$CASP1_120_197__CASP1_317_404__complex: ((NLRP3_elicitors_NLRP3_oligomer_ASC_Procaspase1_complex & CTSG) | (NLRP3_elicitors_NLRP3_oligomer_ASC_Procaspase1_complex & CTSG))
$CASP1_1_119_: (NLRP3_elicitors_NLRP3_oligomer_ASC_Procaspase1_complex & CTSG)
$CASP1_298_316_: (NLRP3_elicitors_NLRP3_oligomer_ASC_Procaspase1_complex & CTSG)
$CO2_simple_molecule_Mitochondrial_Matrix: (((((SUCC_CoA_simple_molecule & Gly_simple_molecule) & sa67_H__ion_Mitochondrial_Matrix) & ALAS1_ALAS2_complex) & !Heme_simple_molecule_Mitochondrial_Matrix) & !Panhematin_drug)
$CO2_simple_molecule_Mitochondrion: ((COPRO3_simple_molecule_Mitochondrion & sa121_O2_simple_molecule_Mitochondrion) & CPOX)
$COPRO3_simple_molecule_Cytosol: (URO3_simple_molecule & UROD)
$COPRO3_simple_molecule_Mitochondrion: COPRO3_simple_molecule_Cytosol
$CO_simple_molecule: (((Heme_simple_molecule_Cytosol & sa24_O2_simple_molecule_Cytosol) & sa25_NADPH_simple_molecule_Cytosol) & sa168_HMOX1_Cytosol)
$Caspase_1_Tetramer_complex: CASP1_120_197__CASP1_317_404__complex
$CoA_SH_simple_molecule: (((((SUCC_CoA_simple_molecule & Gly_simple_molecule) & sa67_H__ion_Mitochondrial_Matrix) & ALAS1_ALAS2_complex) & !Heme_simple_molecule_Mitochondrial_Matrix) & !Panhematin_drug)
$FECH: FECH_rna
$FECH_rna: NRF2_phosphorylated_Nucleus
$FTH1_rna: NRF2_phosphorylated_Nucleus
$FTL_rna: NRF2_phosphorylated_Nucleus
$Fe2__ion_Endosome_Lumen: ((Fe3__ion_Endosome_Lumen & e__ion_Endosome_Lumen) & STEAP3)
$Fe3__ion_Endosome_Lumen: TFRC_holoTF_complex_Endosome_Lumen
$Fe3__ion_default_compartment: ((((sa135_Fe2__ion_default_compartment & sa156_O2_simple_molecule_default_compartment) & sa157_H__ion_default_compartment) & SLC40A1_CP_Cu2__complex) | (((sa135_Fe2__ion_default_compartment & sa212_H__ion_default_compartment) & sa213_O2_simple_molecule_default_compartment) & SLC40A1_HEPH_Cu2__complex))
$Fe_3__O_OH__simple_molecule: (((sa28_Fe2__ion_Cytosol & sa136_O2_simple_molecule_Cytosol) & sa137_H__ion_Cytosol) & Ferritin_complex)
$Ferritin_complex: (FTH1_rna | FTL_rna)
$Ferroptosis_phenotype: Lipid_Peroxide_simple_molecule
$HMBL_simple_molecule: ((PBG_simple_molecule & sa106_H2O_simple_molecule_Cytosol) & HMBS_DIPY_complex)
$HMOX1_rna: (Nrf2_Maf_complex & !BACH1_Maf_complex)
$Heme_simple_molecule_Cytosol: (Heme_simple_molecule_Mitochondrial_Matrix & FLVCR1_2)
$Heme_simple_molecule_Mitochondrial_Matrix: (((PRIN9_simple_molecule_Mitochondrial_Matrix & Fe2__ion_Mitochondrial_Matrix) & FECH) & !Pb2__ion)
$Heme_simple_molecule_default_compartment: ((Heme_simple_molecule_Cytosol & FLVCR1_1) | (((Heme_simple_molecule_Cytosol & sa206_H2O_simple_molecule_Cytosol) & ATP_simple_molecule) & ABCG2))
$IL_18_Cytosol: (proIL_18 & Caspase_1_Tetramer_complex)
$IL_18_default_compartment: IL_18_Cytosol
$IL_1B_Cytosol: (proIL_1B & Caspase_1_Tetramer_complex)
$IL_1B_default_compartment: IL_1B_Cytosol
$Lipid_Peroxide_simple_molecule: (Poly_unsaturated_fatty_acid_simple_molecule & sa165_Reactive_Oxygen_Species_simple_molecule_Cytosol)
$Lipid_alcohol_simple_molecule: (Lipid_Peroxide_simple_molecule & GPX4)
$NH4__ion: ((PBG_simple_molecule & sa106_H2O_simple_molecule_Cytosol) & HMBS_DIPY_complex)
$NLRP3: NLRP3_rna
$NLRP3_SUGT1_HSP90_complex: (((NLRP3_Elicitor_Proteins & NLRP3_SUGT1_HSP90_complex) | (NLRP3_Elicitor_Small_Molecules_simple_molecule & NLRP3_SUGT1_HSP90_complex)) | ((((TXNIP_NLRP3_complex | SARS_E) | SARS_Orf3a) | sa524_Reactive_Oxygen_Species_simple_molecule_Cytosol) & NLRP3))
$NLRP3_elicitors_NLRP3_complex: ((NLRP3_Elicitor_Small_Molecules_simple_molecule & NLRP3_SUGT1_HSP90_complex) | (NLRP3_Elicitor_Proteins & NLRP3_SUGT1_HSP90_complex))
$NLRP3_elicitors_NLRP3_oligomer_ASC_Procaspase1_complex: (NLRP3_elicitors_NLRP3_oligomer_ASC_complex & proCaspase_1)
$NLRP3_elicitors_NLRP3_oligomer_ASC_complex: ((NLRP3_elicitors_NLRP3_oligomer_complex & ASC) | (NLRP3_elicitors_NLRP3_oligomer_ASC_Procaspase1_complex & CTSG))
$NLRP3_elicitors_NLRP3_oligomer_complex: NLRP3_elicitors_NLRP3_complex
$NLRP3_rna: Nf_KB_Complex_complex
$NRF2_phosphorylated_Cytosol: (NRF2_empty & PKC)
$NRF2_phosphorylated_Nucleus: NRF2_phosphorylated_Cytosol
$NRF2_ubiquitinated: csa10_Ubiquitin_Ligase_Complex_complex_Cytosol
$Nrf2_Maf_complex: (NRF2_phosphorylated_Nucleus & MAF)
$PBG_simple_molecule: (dALA_simple_molecule_Cytosol & ALAD_Zn2__complex)
$PPGEN9_simple_molecule: ((COPRO3_simple_molecule_Mitochondrion & sa121_O2_simple_molecule_Mitochondrion) & CPOX)
$PRIN9_simple_molecule_Mitochondrial_Matrix: PRIN9_simple_molecule_Mitochondrion
$PRIN9_simple_molecule_Mitochondrion: ((PPGEN9_simple_molecule & sa124_O2_simple_molecule_Mitochondrion) & PPO_FAD_complex)
$PSTPIP1_trimer_Pyrin_trimer_complex: (Pyrin_trimer_complex & PSTPIP1)
$Pi_simple_molecule: (((Heme_simple_molecule_Cytosol & sa206_H2O_simple_molecule_Cytosol) & ATP_simple_molecule) & ABCG2)
$Pyrin_trimer_ASC_complex: (ASC & Pyrin_trimer_complex)
$SLC40A1_CP_Cu2__complex: SLC40A1_rna
$SLC40A1_rna: NRF2_phosphorylated_Nucleus
$TFRC_TF_complex_Cytosol: TFRC_TF_complex_Endosome_Lumen
$TFRC_TF_complex_Endosome_Lumen: TFRC_holoTF_complex_Endosome_Lumen
$TFRC_holoTF_complex_Cytosol: (TFRC_TF_complex_Cytosol | (Fe3__ion_default_compartment & Transferrin))
$TFRC_holoTF_complex_Endosome_Lumen: TFRC_holoTF_complex_Cytosol
$TXNIP: Oxidized_thioredoxin_TXNIP_complex
$TXNIP_NLRP3_complex: (NLRP3 & TXNIP)
$Thioredoxin_TXNIP_complex: (TXNIP & TXN)
$Transferrin: TFRC_TF_complex_Cytosol
$URO3_simple_molecule: (HMBL_simple_molecule & UROS)
$csa10_Ubiquitin_Ligase_Complex_complex_Cytosol: csa8_Ubiquitin_Ligase_Complex_complex_Cytosol
$csa32_Ubiquitin_Ligase_Complex_complex_Cytosol: csa10_Ubiquitin_Ligase_Complex_complex_Cytosol
$csa8_Ubiquitin_Ligase_Complex_complex_Cytosol: ((!CAND1 | CUL3_RBX1_complex) | ((NRF2_empty & KEAP1) & !Dimethly_fumarate_drug))
$dALA_simple_molecule_Cytosol: dALA_simple_molecule_Mitochondrial_Matrix
$dALA_simple_molecule_Mitochondrial_Matrix: (((((SUCC_CoA_simple_molecule & Gly_simple_molecule) & sa67_H__ion_Mitochondrial_Matrix) & ALAS1_ALAS2_complex) & !Heme_simple_molecule_Mitochondrial_Matrix) & !Panhematin_drug)
$dsDNA_AIM2_complex: (Double_Strand_DNA_simple_molecule & AIM2)
$dsDNA_AIM2_oligomer_ASC_Procaspase_1_complex: (dsDNA_AIM2_oligomer_ASC_complex & proCaspase_1)
$dsDNA_AIM2_oligomer_ASC_complex: (dsDNA_AIM2_oligomer_complex & ASC)
$dsDNA_AIM2_oligomer_complex: dsDNA_AIM2_complex
$proIL_18_1_36_: (proIL_18 & Caspase_1_Tetramer_complex)
$proIL_1B_1_116_: (proIL_1B & Caspase_1_Tetramer_complex)
$sa103_H2O_simple_molecule_Cytosol: (dALA_simple_molecule_Cytosol & ALAD_Zn2__complex)
$sa104_H__ion_Cytosol: (dALA_simple_molecule_Cytosol & ALAD_Zn2__complex)
$sa123_H2O2_simple_molecule_Mitochondrion: ((COPRO3_simple_molecule_Mitochondrion & sa121_O2_simple_molecule_Mitochondrion) & CPOX)
$sa125_H2O2_simple_molecule_Mitochondrion: ((PPGEN9_simple_molecule & sa124_O2_simple_molecule_Mitochondrion) & PPO_FAD_complex)
$sa135_Fe2__ion_default_compartment: ((sa28_Fe2__ion_Cytosol & SLC40A1_CP_Cu2__complex) | (sa28_Fe2__ion_Cytosol & SLC40A1_HEPH_Cu2__complex))
$sa158_H2O_simple_molecule_default_compartment: (((sa135_Fe2__ion_default_compartment & sa156_O2_simple_molecule_default_compartment) & sa157_H__ion_default_compartment) & SLC40A1_CP_Cu2__complex)
$sa162_Fe2__ion_default_compartment: ((Fe3__ion_default_compartment & e__ion_default_compartment) & CYBRD1_Heme_complex)
$sa165_Reactive_Oxygen_Species_simple_molecule_Cytosol: sa28_Fe2__ion_Cytosol
$sa168_HMOX1_Cytosol: (sa29_HMOX1_Cytosol & SARS_CoV_2_Orf3a)
$sa211_H2O_simple_molecule_default_compartment: (((sa135_Fe2__ion_default_compartment & sa212_H__ion_default_compartment) & sa213_O2_simple_molecule_default_compartment) & SLC40A1_HEPH_Cu2__complex)
$sa240_Fe2__ion_Cytosol: (Fe2__ion_Endosome_Lumen & MCOLN1)
$sa26_H2O_simple_molecule_Cytosol: (((Heme_simple_molecule_Cytosol & sa24_O2_simple_molecule_Cytosol) & sa25_NADPH_simple_molecule_Cytosol) & sa168_HMOX1_Cytosol)
$sa27_NADP__simple_molecule_Cytosol: (((Heme_simple_molecule_Cytosol & sa24_O2_simple_molecule_Cytosol) & sa25_NADPH_simple_molecule_Cytosol) & sa168_HMOX1_Cytosol)
$sa28_Fe2__ion_Cytosol: (((((Heme_simple_molecule_Cytosol & sa24_O2_simple_molecule_Cytosol) & sa25_NADPH_simple_molecule_Cytosol) & sa168_HMOX1_Cytosol) | (sa162_Fe2__ion_default_compartment & SLC11A2)) | sa240_Fe2__ion_Cytosol)
$sa29_HMOX1_Cytosol: HMOX1_rna
$sa34_NADP__simple_molecule_Cytosol: (((BLVRB | BLVRA_Zn2__complex) & Biliverdin_simple_molecule) & sa33_NADPH_simple_molecule_Cytosol)
$sa524_Reactive_Oxygen_Species_simple_molecule_Cytosol: !CO_simple_molecule
$sa57_H__ion_Mitochondrial_Matrix: (((PRIN9_simple_molecule_Mitochondrial_Matrix & Fe2__ion_Mitochondrial_Matrix) & FECH) & !Pb2__ion)